Excellent work, your patient tolerated the kidney biopsy well. It’s the day afterwards and your pathologist shows you the H&E stain Click here if you want some quick pathology tips.
Your pathologist tells you that the SV40 (Simian Virus 40) stain was negative, but another immunohistochemistry (IHC) stain was positive:
Which of the following tests below will help you clinch this diagnosis?
Serum and urine BK PCR
The negative SV40 stain makes BK nephropathy unlikely. Try again!
Serum and urine adenovirus PCR
Excellent choice, you find numerous copies of adenovirus in both the serum and the urine! Click below to move on!
Though there is significant interstitial inflammation, urine eosinophils are not a sensitive or specific test for acute interstitial nephritis (AIN) . Further, there are clues in the biopsy that make AIN less likely.
Click here to wrap up this case!
Case 12 Index
Case 12 Introduction
Case 12 Physical Exam
Case 12 Diagnostic Testing