Finally, some additional slide preparations are ready! Take a look into the microscope below…
PAS (Periodic Acid Schiff)
EM (Electron Microscopy)
Which of the following do you see above?
Subepithelial hump-like deposits
Correct! Subepithelial deposits are seen closer to the podocyte (also known as the visceral epithelial cell). Here, they appear large and have a hump-like appearance, and reside under the podocyte foot processes. The podocyte also appears effaced or flattened.
There are definitely deposits here, but subendothelial deposits would be in the basement membrane closer to the endothelial cells. The deposits we see her appear under the podocyte. You’re close, take another shot!
Duplication or “tram-tracking” of the basement membrane
The basement membrane appears to be intact here, with only one layer visible. Try again!
We see deposits in this EM image, but they don’t appear to be in the mesangial space, or the space between the capillary loops. Pick again!
It’s time to lock in your final diagnosis! Choose one before moving on to the end of this case.
Post-infectious glomerulonephritis (PIGN)
Acute interstitial nephritis (AIN)
Systemic lupus erythematosus (SLE) nephritis
Anti-glomerular basement membrane (GBM) disease
Acute tubular necrosis (ATN)
Click here when you’re confident in your final diagnosis!