Case 5: Additional Pathology

Your pathologist informs you the additional slide preparations are ready! Take a look below…

EM (Electron Microscopy)

Screen Shot 2018-07-01 at 10.19.35 AMScreen Shot 2018-07-01 at 10.19.26 AMScreen Shot 2018-07-01 at 10.19.01 AM

Where do you see deposits in the electron microscopy above (more than one answer may be correct!)?
Intramembranous deposits
Correct!
Mesangial deposits
Correct!
Subendothelial deposits
There are no (or very rare) subendothelial deposits, take another look!
Subepithelial deposits
Correct!

IF (Immunofluorescence)

IgG
Screen Shot 2018-07-01 at 10.21.10 AM

IgA
Screen Shot 2018-07-01 at 10.23.16 AM

C3
Screen Shot 2018-07-01 at 10.23.57 AM

C1q
Screen Shot 2018-07-01 at 10.21.10 AM

Confident in your final diagnosis? Lock one in before moving on!
Post-infectious glomerulonephritis (PIGN)
Primary membranous nephropathy
Systemic lupus erythematosus nephritis
Diabetic nephropathy
Hepatitis C-associated glomerular disease
Hepatitis B-associated glomerular disease
Focal segmental glomerulosclerosis (FSGS)
Anti-glomerular basement membrane (GBM) disease
Acute tubular necrosis (ATN)
IgA nephropathy
Minimal change disease

Click here to confirm the diagnosis!

Case 5 Index
Case 5 Introduction
Case 5 Physical Exam
Case 5 Diagnostic Testing
Case 5 Pathology